Freed et al (2001)

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Freed et al (2001)
bắt đầu học
the role of dopamine in Parkinson's disease
Aim
bắt đầu học
To investigate the effects of dopamine on the behavioural symptoms of Parkinson’s disease.
Participants
bắt đầu học
40 patients with severe Parkinson’s disease (mean duration of the disease was 14 years, aging 34-75 years)
Method and design
bắt đầu học
Experiment; independent measures design
Neuroimaging technique
bắt đầu học
PET scan
Procedure 1/2
bắt đầu học
- In the experimental group cells with dopamine producing neurons were taken from aborted embryos and transplanted into the patient's brain (putamen) - In control group skull was drilled but there was no transplantation
Procedure 2/2
bắt đầu học
Patients were followed for one year. PET scans - estimate changes in the brain. Clinical observations and interviews - register changes in symptoms.
Results
bắt đầu học
PET scans revealed significant growth of dopamine producing cells in putamen of transplant group. Patients in the transplant group represented reduction of disease by 28% (only in the relatively younger group - below 60)

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